What Does Sign Up Now Mean?
What Does Sign Up Now Mean?
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The undifferentiated nucleotide specificities of specific archaeal ligases have tantalizing implications for enzyme evolution and also the probable use of ADP as a substrate by ancestors of contemporary DNA ligases. The flexibility of some archaeal ligases to utilize ATP and NAD+ or ATP and ADP as substrates could possibly be defined when they regarded just the ADP component popular to all three nucleotides.
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The four-level binding on the HhH domain on the periphery on the LigA·DNA footprint stabilizes a DNA bend centered for the nick. The LigA-DNA interactions quickly flanking the nick induce a local DNA distortion, leading to adoption of the RNA-like A-sort helix, yet again echoing the results with the HuLig1·DNA cocrystal.
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